Similarly, HTP use was associated with increased IL-8, IL-6, and IL-2 levels (p < 0.05), as well as higher white blood cell (WBC), leukocyte (p < 0.05), and eosinophil levels (p < 0.01), and an increase in the inflammatory response (p < 0.01), followed by endothelial dysfunction [52]. This evidence concerns the gene CXCL8 and endothelial dysfunction.