Recent studies highlight the value of novel biomarkers—kidney injury molecule-1 (KIM-1) [7,8,9], neutrophil gelatinase-associated lipocalin (NGAL) [10,11,12], and trefoil factor 3 (TFF3) [13,14]—for early detection of tubular injury and CKD risk. This evidence concerns the gene LCN2 and chronic kidney disease.