Deregulation of stem cell pathways such as perturbation tumor protein p53 (TP53), MYC proto-oncogene, bHLH transcription factor (MYC) networks [9], and Wingless-related Integration Site (WNT) signaling activation [10], or interaction between MYC and transcription factor 7-like 2 (TCF7L2) at the chromatin level [11], have also been described during CML blast crisis. The gene discussed is MYC; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.