In CML leukemic stem cells, PIM2 expression is promoted by both a BCR::ABL-dependent (IM-sensitive) Signal Transducer and Activator of Transcription 5 (STAT5)-mediated pathway and a BCR::ABL-independent (IM-resistant) Signal Transducer and Activator of Transcription 4 (STAT4)-mediated pathway [60]. This evidence concerns the gene BCR and chronic myelogenous leukemia, BCR-ABL1 positive.