During the chronic phase of CML, after single-cell trajectory reconstitution on prognosis phenotype, CD63 regulation highlighted a trajectory cluster implicating HSPB1, PIM2, ANXA5, LAMTOR1, CFL1, CD52, RAD52, MEIS1, and PDIA3 molecules characterizing hematopoietic malignancies like myelodysplasia, acute myeloid leukemia, and acute lymphoid leukemia. The gene discussed is ANXA5; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.