In periodontitis-affected tissues, the beneficial effect of PPARG expression is regulation of the inflammatory response through the suppression of various inflammatory mediators, such as interleukin-1 beta (IL-1β), IL-6, IL-8, tumor necrosis factor-alpha (TNF-α), prostaglandin E2, and matrix metalloproteinases (MMPs). This evidence concerns the gene TNF and periodontitis.