Meanwhile, pregnant wild-type mice treated with Notch1 inhibitor LY-411575 displayed postpartum ventricular dilatation, myocardial hypertrophy, and interstitial fibrosis and reduced myocardial angiogenesis; moreover, inhibition of Notch1 markedly increased Cat-D and sFlt-1, and reduced phosphorylated STAT3 and VEGF [42]. Here, NOTCH1 is linked to cardiac hypertrophy.