AKT1 and Parkinson disease: Similarly, in Parkinson’s Disease (PD), maladaptive AKT-GSK3β signaling can be observed in dopaminergic neurons, where persistent Y216 phosphorylation of GSK3β is combined with a loss of β-catenin translocation to the nucleus; this facilitates apoptotic favor and the destabilization of the Wnt-mediated transcriptional programme.