Genome-wide sequencing of chromatin accessibility using ATAC-seq and ChIP-seq have illustrated parallel findings in AD and frontotemporal dementia (FTD): diminished chromatin accessibility at neuronal enhancers en-marked by H3K27ac and H3K4me1, and particularly at loci that direct synaptic vesicle cycling and neurotrophin response [8]. This evidence concerns the gene BDNF and frontotemporal dementia.