CD274 and neoplasm: Next-wave interventions pair metabolic brakes with programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) or heat shock protein 90 (HSP90) blockade, deploy AhR antagonists, phytochemicals, or AhR inhibitors such as BAY2416964 to restore immunity and curb tumor growth [136].