To further illuminate the biological functions of CBR1 and PRDX1 in COPD pathogenesis, GSEA was performed and indicated that CBR1 was significantly enriched in several pathways, including O-glycan biosynthesis, metabolism of xenobiotics by cytochrome P450, glutathione metabolism, the pentose phosphate pathway, and oxidative phosphorylation (Figure 4C). This evidence concerns the gene PRDX1 and chronic obstructive pulmonary disease.