Four key LRGs were shared among DEGs, genes from the key WGCNA module, and the previously reported LRGs in COPD: Carbonyl Reductase 1 (CBR1), Glucose-6-Phosphate Dehydrogenase (G6PD), Peroxiredoxin 1 (PRDX1), and Transketolase (TKT) (Figure 2A; Supplementary Table S5). This evidence concerns the gene G6PD and chronic obstructive pulmonary disease.