Although the predominant role has historically been highlighted in viral-related chronic liver disorders, adaptive immunity, mediated by diverse subsets of T (CD4+, CD8+, γδ, and Treg) and B cells (transitional, memory, regulatory, etc.), is increasingly recognized as a key player also in MASLD and its progression to MASH [90,91,92,93]. Here, CD4 is linked to metabolic dysfunction-associated steatotic liver disease.