Crucially, Rui Xu et al. demonstrated that MCK-directed GALGT2 expression unexpectedly mitigated dystrophic cardiomyopathy in mdx models, revealing intrinsic dual cardioskeletal tropism, a discovery with profound implications for Duchenne muscular dystrophy (DMD) management given its cardiac manifestations [68]. This evidence concerns the gene CKM and Duchenne muscular dystrophy.