Dystrophinopathies, including Duchenne muscular dystrophy (DMD) and Beck muscular dystrophy (BMD), predominantly arise from variants in the X-chromosomal DMD (dystrophin) gene, leading to loss of dystrophin, which disrupts the critical dystrophin–glycoprotein complex (DGC) [8]. The gene discussed is ART4; the disease is Duchenne muscular dystrophy.