DMD and Duchenne muscular dystrophy: Manuela Chiper et al. and Shani Attias Cohen et al. utilized a hydrogel-based polymeric carrier in the form of injectable PEG-fibrinogen (PF) microspheres for the delivery of chemically modified 2′-O-methyl phosphorothioate (2OMePs) antisense oligonucleotides (AONs), achieving exon-skipping-mediated restoration of dystrophin expression in the skeletal muscle of DMD model mice [99,100].