In contrast, Facioscapulohumeral muscular dystrophy (FSHD) is associated with epigenetic de-repression of the DUX4 (double homeobox 4) gene, which leads to aberrant expression of the transcription factor DUX4 and cytotoxicity in skeletal muscle cells [9]. This evidence concerns the gene DUX4 and facioscapulohumeral muscular dystrophy.