RB1 and cancer: Dysequilibrium of histone acetylation has been associated with cancer pathogenesis, ref. [59] and HDACs play a key role in this process—interaction with Rb to form the HDAC–Rb repressor complex regulates genes involved in the G1/S phase of the cell cycle through deacetylation of histones, which then causes condensation of the chromatin structure and reduced expression of important tumor suppressor genes [60].