Systemic inflammation and activation of pro-inflammatory cytokines, such as interleukin 6 (IL6) and tumor necrosis factor (TNF) alpha, is also a matter of high importance that needs monitoring, as it affects early fetal organ (liver, adipose tissue, brain, skeletal muscle, and pancreas) development, thereby precipitating metabolic disorders [27,28]. The gene discussed is TNF; the disease is metabolic disease.