This pathway inhibition leads to the dephosphorylation and reduced activity of components like 3-phosphoinositide-dependent kinase 1, Akt1, and the mTOR receptor, as well as the BRAF/MKK/ERK1/2 signaling pathway, resulting in cell cycle arrest and apoptosis in pancreatic cancer cells. Here, AKT1 is linked to familial pancreatic carcinoma.