Melanoma is a particularly aggressive tumor with a poor prognosis that may be influenced by genetic factors (i.e., BRAF mutation) [28], in fact BRAF wild-type (CHL-1) and mut (A375) cells have been widely used in the field of melanoma [29,30,31,32] and these cell lines were also used in our experimental model to provide a translation impact. Here, BRAF is linked to neoplasm.