CRP and Increased total leukocyte count: These include elevated C-reactive protein (CRP), anemia, elevated transaminases, hypoalbuminemia (≤3.0 g/dL), hyponatremia, thrombocytosis (platelet count > 450,000/μL), leukocytosis (white blood cell count ≥ 15,000/μL), cerebrospinal fluid pleocytosis, and sterile pyuria [61,70].