IL6 and chronic kidney disease: Specifically, dogs that undergo subtotal nephrectomy and RDN have shown significantly lower blood pressure, attenuation of LVH and CKD-induced ECG changes, higher ventricular fibrillation threshold, and lower levels of serum noradrenaline, C-reactive protein and interleukin-6 compared with CKD dogs without RDN 6 weeks after the surgical procedure [64].