FMO5 and chronic kidney disease: Moreover, 3 weeks after selective afferent RDN (by painting the renal artery with a solution of capsaicin), rats with CKD had lower blood pressure, lower serum creatinine, decreased levels of urine protein, decreased renal and splanchnic sympathetic nerve activity (SNA), reduced renal fibrosis by 45%, reduced in-renal infiltration of macrophages, as well as lower renal hydrogen peroxide levels and NADPH oxidase activity compared with CKD rats without RDN [60].