LAMB2 encodes an extracellular matrix protein crucial for pituitary morphogenesis, and biallelic LAMB2 mutations can lead to GHD, developmental delay, focal segmental glomerulosclerosis, and congenital nephrotic syndrome, while a brain MRI might reveal anterior pituitary hypoplasia and optic nerve hypoplasia [58]. This evidence concerns the gene LAMB2 and Autosomal dominant optic atrophy, classic type.