Through the analysis of lung tissues from mice at various time points (0, 7, 14, and 21 days) post BLM administration, we observed a correlation between the progression of PF and the gradual increase in the expression levels of fibrotic markers alongside a concomitant 2.15-fold rise in SIK2 protein levels (p < 0.05) (Figure 1B). Here, SIK2 is linked to pemphigus foliaceus.