FoxO1, a forkhead transcription factor, was found to be overexpressed in granulosa cells of PCOS rats, as reported by Huang et al. [15] FoxO1 knockdown alleviated ovarian inflammation and fibrosis, promoted granulosa cell proliferation, and suppressed activation of the TLR4/NF-κB/NLRP3 inflammasome pathway. The gene discussed is FOXO1; the disease is polycystic ovary syndrome.