Genome-wide association studies (GWAS) have expanded this list, identifying novel loci such as THADA, TOX3, YAP1, and AMH/AMHR2 that influence diverse aspects of PCOS pathophysiology, including folliculogenesis, metabolic regulation, and hormonal homeostasis [12,37,38,39]. This evidence concerns the gene TOX3 and polycystic ovary syndrome.