The heart hypertrophy markers atrial natriuretic peptide (ANP) and myosin heavy chain beta (β-MHC) were also diminished after miR-335-5p inhibition, suggesting that miR-335-5p is associated with right ventricular remodeling in PAH, and that its inhibition attenuates this process [45]. This evidence concerns the gene NPPA and cardiac hypertrophy.