Further investigations uncovered that miR-340-5p repressed PASMC proliferation and migration by restraining IL-6 and IL-1β, consequently preventing apoplexy and PAH improvement in a rodent model, and that upregulation of miR-340-5p hinders the NF-κB pathway and NF-κB pathway by restraining IL-6 or IL-1β-prompted irritation. Here, NFKB1 is linked to pulmonary arterial hypertension.