IFNG and psoriasis: However, a paradox exists in so far as IFN-γ and IL-12p40 are critical for the preservation of cancer immunity in the presence of anti-PD-1 therapy on the one hand [36], while on the other hand autoimmune pathologies such as psoriasis [37,38] and systemic lupus erythematosus (SLE) [39] are linked to the presence of these cytokines.