We have previously reported the peptide-mediated induction of activating receptors (NKG2D/NKp44) in NK cells [25] and suggest that, in combination with increased numbers of pSTAT4-expressing NK cells in the presence of IK14004, this may compensate for the peptide’s suppressive effect on the IL-12p40/IFN-γ feedback loop considered responsible for anti-PD-1 efficacy in cancer patients [36]. The gene discussed is KLRK1; the disease is cancer.