IFNG and Autoimmunity: A paradox exists in immune checkpoint inhibitor (ICI) therapy in so far as IFN-γ and IL-12p40 appear critical for the preservation of cancer immunity in the presence of anti-PD-1 therapy on the one hand [36], while on the other hand autoimmune pathologies such as psoriasis [37,38,40] and systemic lupus erythematosus [39] are linked to the presence of these cytokines.