CXCL8 and colorectal carcinoma: In CRC, enoyl-CoA δ-isomerase 2 (ECL2) reduces ether-lipid-mediated IL-8 expression in CRC cells by repressing the peroxisomal localization of alkylglycerone phosphate synthase, thereby suppressing the neutrophil recruitment and NETs formation, which suggests the anti-tumor role of ECL2 [114].