NRAS and melanoma: Similarly, the Cancer Genome Atlas (TCGA) classification highlights that triple wild-type melanomas, common in acral and mucosal locations, show substantially reduced UV mutational signatures and lower mutation rates compared to B-RAF Proto-Oncogene, Serine/Threonine Kinase (BRAF-), neuroblastoma RAS viral oncogene homolog (NRAS-), and neurofibromin 1 (NF1) mutated subtypes [6].