We next evaluated effect of ME conditions in vitro on activation of key cancer-promoting signal transduction pathways implicated in crosstalk with TLR4 signaling cascade (reviewed in [48,49]) as well as in breast tumorigenesis, and known to be triggered by the aforementioned cytokines [6,50], i.e., STAT3 and AKT. This evidence concerns the gene AKT1 and cancer.