AdipoRon mitigated anxious and depressive-like behaviors in the rat model of PD by principally modulating the AMPK/Sirt-1 (↓NLRP3, IL-1β, CAS-1, and ↑Sirt-1) signaling pathway and blocking the NLRP3 inflammasome. This evidence concerns the gene SIRT1 and Parkinson disease.