The development of hypomagnesemia is often attributed to renal magnesium wasting, primarily due to the downregulation of the renal expression of epidermal growth factor (EGF) and the magnesium channel TRPM6 in the distal collecting tubule [75]; there may also be a shift of magnesium into cells, further contributing to these phenomena [75]. Here, TRPM6 is linked to familial primary hypomagnesemia.