The green cluster functions as a basic theme/motor theme that underpins fundamental pathogenic mechanisms, with Fetuin-A identified as a potential diagnostic hepatokine exhibiting elevated serum concentrations in MASLD patients compared to controls, correlating with ultrasound steatosis grades and insulin resistance through AMPK inhibition [36,37,38,39,40,41,42]. This evidence concerns the gene AHSG and metabolic dysfunction-associated steatotic liver disease.