Genetic susceptibility to higher plasma levels of ICOSLG, ERBB2, ALDH2, FCGR3A, PAM, TNFAIP3, CD40, MFAP2, BCL2L15, HAPLN4, SUGP1, FCRL3, OLFML3, PADI4, WASL, POLR2F, IGSF11, and ADPGK correlated with increased RA risk, while NFKBIE, CCL21, IL6R, CD28, FCGR2A, FLT3, IFNGR2, SPRED2, CCL19, CELF2, H2AZ1, H2BC21, H2AC25, and H2BC26 showed inverse associations (Figure 2). This evidence concerns the gene FCRL3 and rheumatoid arthritis.