Among them, nine genes (FCGR3A, FCGR2A, TNFAIP3, CD40, FLT3, MFAP2, HAPLN4, FCRL3, and OLFML3) demonstrated expression levels that were associated with RA risk in consistent effect directions across different tissues, aligning with those observed in plasma protein levels. This evidence concerns the gene MFAP2 and rheumatoid arthritis.