With East Asian RA, some proteins were not available, and CCL21, ALDH2, CD28, FCGR2A, PAM, CCL19, CELF2, H2AC25, and H2BC26 no longer exhibited significant causal effects on RA, while BCL2L15 and OLFML3 showed effects opposite to those observed in the discovery stage. The gene discussed is CD28; the disease is rheumatoid arthritis.