Based on our initial IVW data analysis, after adjusting for multiple comparisons using the false discovery rate (FDR < 0.05), we observed positive causal links between serum urate concentrations and CHD (OR = 1.08, 95% CI = 1.03–1.14, p = 0.0011), SAP (OR = 1.22, 95% CI = 1.15–1.30, p = 4.48 × 10−10), UAP (OR = 1.26, 95% CI = 1.17–1.35, p = 2.49 × 10−10), MI (OR = 1.17, 95% CI = 1.08–1.27, p = 0.00018), and ischaemic stroke excluding all haemorrhages (OR = 1.0016, 95% CI = 1.0004–1.0027, p = 0.0077) (Figure 3B; Supplementary Table S9). The gene discussed is UBAP1; the disease is coronary artery disorder.