Recent research employing integrative bioinformatics analyses of CD34+ hematopoietic stem/progenitor cell gene expression datasets (GSE2779, GSE4619, and GSE19429) has identified significant downregulation of immune-associated genes in MDS patients, specifically RAG1, PAX5, VPREB1, CD19, and IL7R, which are implicated in B-cell development, V(D)J recombination, and antigen receptor signaling. The gene discussed is RAG1; the disease is myelodysplastic syndrome.