The use of protein–protein interaction (PPI) network construction via Search Tool for the Retrieval of Interacting Genes (STRING) and Cytoscape software (version 3.10.2) allowed for the identification of twelve hub genes with high centrality scores, many of which (e.g., PAX5, RAG1, and BACH2) are critical in adaptive immunity and are known to be inactivated or silenced in both MDS and lymphoid malignancies. The gene discussed is PAX5; the disease is myelodysplastic syndrome.