AKT1 and ovarian cancer: Both by itself and in conjunction with cisplatin, oleanolic acid demonstrated apoptotic effects, such as an increase in reactive oxygen species (ROS), p38 protein mitogen-activated protein kinase (the MAPK pathway), and apoptotic signal-regulating kinase 1 (ASK1), and its suppression effect on human ovary cancer cell line A2780, A2780ZD0473R, and A2780cisR on signaling pathways such as ribosomal subunit S6 kinases (S6K), PI3K, mTOR, or Akt, and NF-κB (Figure 19).