Curcumin has been shown to impact a number of cell signaling pathways, including those involved in the development of cancer: growth (HER-2, EGFR, or AP-1), the cycle of cells (cyclin D1 or cyclin E), swelling (NF-κB, TNF, IL-6, and IL-1, COX-2, or 5-LOX), cell death (caspase activation and reduction of anti-apoptotic peptides), survival (PI3K/AKT route), the growth of vessels (VEGF), invasion (MMP-9 or bonding molecules), or metastasis (CXCR-4), as shown in Figure 6. The gene discussed is EGFR; the disease is cancer.