IQGAP1 interaction with microtubules via β-tubulin and with intermediate filaments such as CK7 may serve to orchestrate changes in cellular motility by forming podosomes/invadosomes in a number of tumor cells [14], as our results indicate, via the presence of truncated PALB2, which can lead to changes in the spatial distribution and function of IQGAP1 within tumor cells, ultimately leading to extravasation and metastasis [16,18]. This evidence concerns the gene PALB2 and neoplasm.