In control samples, IQGAP1 displayed clear specific immunofluorescence at a medium intensity level in the periphery of cytosol and plasma membrane of tumor cells (white arrowheads) with no interphase between cells and the CK7 fluorescence signal at heterogeneous, high to saturated intensity in the cytosol of tumor cells with evident interphase space between cells. The gene discussed is IQGAP1; the disease is neoplasm.