IQGAP1 (IQ motif containing GTPase activating protein 1) is a remarkably flexible scaffolding multidomain protein that regulates complex cellular processes and signaling pathways, such as cell fate, cell migration, cell cycle, angiogenesis, and many others, most of them being involved in proliferation, tumorigenesis, cancer, and cell migration [13,14]. This evidence concerns the gene IQGAP1 and cancer.