Quantitative analysis of confocal microscopy images revealed distinct patterns of IQGAP1 and PALB2 expression across the two different ductal breast carcinomas after probing with anti-IQGAP1 antibody and anti-C-terminus PALB2 Ab; both cases reported in this study lack the BRCA2-interacting domain. Here, IQGAP1 is linked to breast ductal adenocarcinoma.