AKAP12 and Myocardial fibrosis: Recent studies focusing on myocardial fibrosis have shed light on the interaction between MR and aldosterone, revealing that this signaling axis leads to the downregulation of A-kinase anchoring protein 12 (AKAP12), a member of the AKAP family that is involved in coordinating various essential cellular functions, including myofibroblast differentiation, cell proliferation, and the secretion of extracellular matrix components like collagen [55].