REN and cancer: Pathway enrichment analysis using KEGG, Reactome, and WP revealed that hub genes were predominantly involved in the Estrogen signaling pathway (KEGG:04915), Endocrine resistance (KEGG:01522), Wnt signaling (KEGG:04310), PI3K-Akt signaling (WP:WP4172), and other cancer-related pathways, including FoxO signaling (KEGG:04068), Renin-angiotensin system (KEGG:04614), Chemical carcinogenesis—receptor activation (KEGG:05207), and innate immune system processes (REAC:R-HSA-168249).