CAMP and skin infection: This study aims to analyze and optimize the antimicrobial activity of CAP-18 against a collection of P. aeruginosa clinical isolates, through the synthesis of peptide analogs derived from its structure, defining the peptides’ in vitro biological profile against human cell lines and erythrocytes, determining its bactericidal activity, obtaining a first approach on the effect of CAP-18 molecules on the bacterial membrane through Transmission Electron Microscopy (TEM) and finally to carry out an investigation of its in vivo effectiveness in a skin infection mouse model by P. aeruginosa.