In addition to immune activation markers, several routinely available indices capture distinct axes of burn sepsis: prothrombin time (PT) as a surrogate of sepsis-induced coagulopathy [12]; hematocrit (Hct) to contextualize resuscitation and hematologic dynamics, with early Hct trajectories being informative in burns [13]; and D-dimer as a readout of fibrin formation and lysis that is associated with adverse outcomes in sepsis and reflects coagulation pathway activation pertinent to critical care for burns [14]. This evidence concerns the gene F2 and Sepsis.