Furthermore, oral dysbiosis may affect systemic health through pro-inflammatory mediators (e.g., IL-6 and TNF-α), transient bacteremia, immune cross-reactivity, and microbial translocation (e.g., LPS), contributing to diseases such as cardiovascular and metabolic disorders via the oral–gut–systemic axis [41,51,52,53]. The gene discussed is IL6; the disease is Other metabolic disease.