APC and colorectal carcinoma: Because APC mutation, which usually occurs first in the progression of CRC and converts normal epithelium into hyperplastic epithelium, was not associated with the survival probability of patients with colon adenocarcinoma (Figure 1b), we focused on TP53 and KRAS and found that their mutations were separately paralleled by a lower relapse-free survival (Figure 1b), implicating their critical roles in the progression of colorectal carcinogenesis.