TP53 and malignant colon neoplasm: In addition to suggesting critical roles of TP53 and KRAS genes in the tumorigenesis of CRC (Figure 1), results from the Kaplan–Meier Plotter database further showed that a lower expression of the SLC40A1 gene (solute carrier family 40 member 1, encoding for the protein that is involved in iron export to the outside of the cell) in colon cancer patients with wild-type TP53 or mutant KRAS had a lower relapse-free survival (Figure 4a).