Furthermore, CRC patients displayed higher mRNA levels of SLC7A11 (encoding for solute carrier family 7 member 11, an anionic amino acid transport system Xc− that imports cystine for glutathione biosynthesis) and ACSL4 (encoding for acyl-CoA synthetase long chain family member 4, an arachidonic acid and CoA combination catalyzer that elevates polyunsaturated fatty acid-containing phospholipids) (Figure 1c). This evidence concerns the gene ACSL4 and colorectal carcinoma.