Our previous report indicates that human hepatocellular carcinoma HepG2 cells with an increased expression of nuclear receptor co-activator 4 (NCOA4), a cargo receptor of ferritinophagy, and reduced expression of FTH1, a subunit of iron storage protein ferritin, are more prone to formosanin C-induced ferroptosis than Hep3B cells [29]. The gene discussed is NCOA4; the disease is hepatocellular carcinoma.