The impact of SEPS1 knockdown using small interfering RNA (siRNA) was evaluated in a murine model of sepsis induced by lipopolysaccharide (LPS) [90], showing a reduction in SEPS1 expression and the subsequent production of TNF α and IL 6 observed in the SEPS1 siRNA group, which could be linked to the activation of the p38 MAPK pathway. This evidence concerns the gene TNF and Sepsis.