The same authors showed that gene silencing with HDAC9 recombinant lentivirus in vivo mitigated cerebral injury in experimental stroke and improved brain microvessel endothelial cell dysfunction caused by increased neuroinflammatory responses, cellular apoptosis, and endothelial cell permeability associated with reduced expression of tight-junction proteins in the oxygen–glucose deprivation model [64]. Here, HDAC9 is linked to stroke disorder.