HDAC2 and Stroke: HDAC2 levels increase in neurons and astrocytes 4–24 h after stroke, driving deacetylation of histone protein H3 at the ninth lysine residue (H3K9) and contributing to apoptosis and astrocyte reactivity, supported by co-localization of HDAC2 with TUNEL (Terminal deoxynucleotidyl transferase dUTP Nick End Labeling)-labeled cells in the penumbra photothrombotic stroke (PTS) being induced [49].