HDL particles, widely recognized for their utility in reverse cholesterol transport and physio-pathological roles in cardiovascular diseases, also exert important antioxidant and anti-inflammatory properties as they inhibit LDL oxidation, cytokine-induced production of endothelial cell adhesion molecules, and ox-LDL-induced MCP-1 production by endothelial cells, thereby modulating inflammatory processes through different molecular mechanisms [23,24,34,35]. Here, ESAM is linked to cardiovascular disorder.