Our data confirmed the diminished expression of HO-1 in the DRG of CIS-injected male (p < 0.001, one-way ANOVA; Figure 12A) and female mice (p < 0.001, one-way ANOVA; Figure 12B) as compared with their corresponding VEH-VEH-VEH treated animals. The gene discussed is HMOX1; the disease is in situ carcinoma.