Finally, the nonchanges in the expression of NQO1 in the DRG of CIS-injected mice treated with VEH, DULO, HRW, and DULO plus HRW were consistent with those observed in paclitaxel-injected and nerve-injured mice treated with HRW [11,53], suggesting that this detoxicant enzyme is not involved in these activities. This evidence concerns the gene NQO1 and in situ carcinoma.