Indeed, altered lipid peroxidation, reflected in elevated levels of 4-hydroxynonenal (4-HNE) with consequent exacerbation of oxidative stress [17], and decreased activity of the antioxidant enzymes superoxide dismutase 1 (SOD-1) and heme oxygenase 1 (HO-1) in the dorsal root ganglia (DRG) and prefrontal cortex (PFC) of CIS injected-mice have been demonstrated [18]. The gene discussed is SOD1; the disease is in situ carcinoma.