In contrast to these results, nonchanges in the expression of 4-HNE, HO-1, SOD-1, and NQO1 in the AMG of CIS-injected mice were detected, thus suggesting that this brain area seems not to be severely affected by this type of chemotherapy as it is with paclitaxel, which increases the AMG expression of 4-HNE [53]. Here, HMOX1 is linked to in situ carcinoma.