Additionally, whereas the administration of DULO and HRW alone and combined normalized the oxidative and inflammatory reactions caused by CIS in the DRG of both male and female mice, an overexpression of NLRP3 was identified in the AMG of male and female mice treated with DULO plus HRW (p < 0.003, one-way ANOVA; Figure 11C,D). The gene discussed is NLRP3; the disease is in situ carcinoma.