NLRP3 and in situ carcinoma: Indeed, the peripheral oxidative and inflammatory reactions triggered by CIS were proved with the increased expression of 4-HNE (p < 0.001, one-way ANOVA; Figure 10A,B) and NLRP3 (p < 0.002, one-way ANOVA; Figure 10C,D) in the DRG of male and female mice.