NLRP3 and neuropathy: Because of the well-known participation of oxidative stress, inflammation, and neuronal plasticity in the progression of neuropathy caused by CIS and the accompanying mental diseases, we evaluated the impact of treatment with DULO and HRW alone and combined on the protein levels of 4-HNE, the NLRP3 inflammasome, and p-JNK in the DRG and AMG of CIS-injected male and female mice (Figure 10 and Figure 11).