For example, studies on extracts from Coreopsis tinctoria Nutt., specifically focusing on luteolin, marein, naringenin (NGN), and chlorogenic acid (CQA), demonstrated their capacity to downregulate HMGCR expression in HepG2 cells exposed to oleic acid (OA), a model system for hyperlipidemia. Here, HMGCR is linked to hyperlipidemia.