HMGCR and alcoholic liver diseases: Similarly, hydroxysafflor yellow A (HSYA) in the context of alcoholic liver disease, and apigenin triacetate for hypercholesterolemia-associated neurodegeneration, exhibited strong binding affinities toward HMGCR, PPARA, and PPARG through molecular docking, hinting at their roles in mitigating lipid accumulation and inflammation [49,52].