CD274 and head and neck squamous cell carcinoma: Another mechanism of Nrf2-driven ferroptosis resistance involves the upregulation of TXNRD1, as recently reported by Hsieh et al. TXNRD1 overexpression maintained cellular redox balance and suppressed ferroptosis while simultaneously promoting programmed death-ligand 1 (PD-L1) expression and immune evasion in HNSCC [33].