Compared to lung cancer and glioblastoma (GBM), which often rely on SLC7A11 and GPX4 overexpression for ferroptosis evasion, HNC appears to exhibit distinct ferroptosis resistance patterns through Nrf2-mediated transcriptional upregulation of FSP1, HO-1, and lipid metabolic enzymes [15]. The gene discussed is GPX4; the disease is glioblastoma.