NFE2L2 and head and neck squamous cell carcinoma: For instance, overexpression of AlkB homolog 5, RNA demethylase (ALKBH5) stabilizes NFE2L2 mRNA via N6-methyladenosine (m6A) demethylation and insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) binding, leading to increased resistance to ferroptosis in hypopharyngeal HNSCC [29].