SASP is regulated via both DDR-dependent mechanisms (via NF-κB and CCAAT/enhancer-binding protein beta [C/EBPβ]) and DDR-independent pathways, such as cyclic GMP-AMP synthase–stimulator of interferon genes (cGAS–STING)-mediated sensing of cytoplasmic DNA fragments derived from compromised nuclear integrity or infection-related stimuli [2,119,120]. Here, CGAS is linked to infection.