However, in a mouse model of PM2.5-induced pulmonary fibrosis, the level of oxidative DNA damage in the lungs of mice was elevated when they were exposed to particulate matter for a period of time, and OGG1 deficiency exacerbated PM2.5-induced oxidative stress, death of type 2 alveolar epithelial cells (AEC2s), and pulmonary fibrosis in mice [65]. This evidence concerns the gene OGG1 and pulmonary fibrosis.