This condition is defined by the presence of kidney damage, commonly manifested as proteinuria, a urine albumin-to-creatinine ratio (UACR) ≥ 30 mg/g, an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2, or structural/functional renal abnormalities (e.g., urinary sediment alterations, imaging findings, or histological changes) that persist for at least three months, with or without renal function deterioration, in accordance with international CKD guidelines [5,6]. The gene discussed is ALB; the disease is chronic kidney disease.