Figure 2 illustrates that among the 80 genes identified as differentially expressed in AD, 47 were under-expressed and 33 were over-expressed, including NFE2L2, which was found to be over-expressed. Furthermore, differential expression was observed in five NRF2 partners following EVOO consumption. Among these, three were found to be over-expressed (FLJ1, NFE2, CASP1), while two were under-expressed (REL, JUN). It is noteworthy that JUN is upregulated in AD and downregulated following EVOO consumption. DEGs in AD and EVOO are detailed in Supplementary S2. The gene discussed is REL; the disease is Alzheimer disease.