NFE2 and Alzheimer disease: Figure 2 illustrates that among the 80 genes identified as differentially expressed in AD, 47 were under-expressed and 33 were over-expressed, including NFE2L2, which was found to be over-expressed. Furthermore, differential expression was observed in five NRF2 partners following EVOO consumption. Among these, three were found to be over-expressed (FLJ1, NFE2, CASP1), while two were under-expressed (REL, JUN). It is noteworthy that JUN is upregulated in AD and downregulated following EVOO consumption. DEGs in AD and EVOO are detailed in Supplementary S2.