Given that Glo1 shows reduced activity in neurodegenerative diseases, leading to increased accumulation of MGO and AGEs in brain tissue [25], which has been correlated with cognitive decline in humans and rodents [21,22,23,24], and that previous data from our laboratory identified low levels of Glo1 in the brains of age-accelerated SAMP8 mice [26], we asked if Glo1 overexpression (Glo1 OEX) would modify the aging phenotype of this mouse model. This evidence concerns the gene GLO1 and Mental deterioration.