STAR and granulosa cell tumor: siRNA-mediated knockdown of ATG5 or BECN1 in KGN cells, a granulosa cell tumor–derived cell line, attenuates autophagy, reduces expression of GCs’ differentiation markers, such as cytochrome P450 family 19 subfamily A member 1 (CYP19A1), FSHR, and steroidogenic acute regulatory protein (StAR), and lowers estradiol synthesis [24].