Moreover, follicular fluid progesterone concentrations are higher in these patients, and endometriosis-derived GCs with activated autophagy exhibit increased expression of steroidogenic enzymes (StAR, CYP11A1, HSD3B2), mirroring the progesterone decrease observed in Becn1-deficient ovarian models, implicating an essential role of autophagy in progesterone regulation. This evidence concerns the gene BECN1 and endometriosis.